Michelle Elias

About

M.Sc. student in Biophysics at Humboldt University of Berlin
Focus on systems biology, systems medicine, and computational pharmacology
Research interests include PBPK modeling and digital twins
Development of reproducible model pipelines for model-informed precision dosing
Contributor to DFG SPP 2311 starting March (SPP-FEMVis web platform for FEM simulation visualization)
Working in the research group of Dr. Matthias König

Publications

Reproducibility of a Digital Twin of Canagliflozin Pharmacokinetics and Pharmacodynamics in Type 2 Diabetes Mellitus

Elias M, Myshkina M, Tereshchuk V, and König M · Physiome, 2026 · First Author

Submitted Code

A Digital Twin of Canagliflozin Pharmacokinetics and Pharmacodynamics in Type 2 Diabetes Mellitus

Tereshchuk V, Elias M, and König M · Preprints, 2026 · Co-Author

Submitted Preprint Code

Rivaroxaban Pharmacokinetics and Coagulation Effects: Reproducibility of a Physiologically Based Modeling Approach

Myshkina M, Elias M, Casabianca E, and König M · Physiome, 2026 · Second Author

Submitted Code

Reproducibility of a Digital Twin of the Angiotensin II Receptor Blocker Losartan

Myshkina M, Elias M, Tensil E, and König M · Physiome, 2026 · Second Author

Accepted DOI Code

Reproducibility of a Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Model of Dapagliflozin

Elias M, Myshkina M, Nemitz N, and König M · Physiome, 2026 · First Author

Accepted DOI Code

A Physiologically Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Model of Dapagliflozin in Type 2 Diabetes Mellitus: The Effect of Dosing, Hepatorenal Impairment, and Food

Nemitz N, Elias M, and König M · Pharmaceutics, 2026 · Co-Author

Published DOI Preprint Code

Reproducibility of a Digital Twin of Glimepiride for Personalized and Stratified Diabetes Treatment

Elias M and König M · Physiome, 2025 · First Author

Published DOI Code

A digital twin of glimepiride for personalized and stratified diabetes treatment

Elias M and König M · Frontiers in Pharmacology, 2025 · First Author

Published DOI Preprint Code Web App

Thesis

A physiological-based pharmacokinetic (PBPK) model of the sulfonylurea glimepiride

Bachelor’s Thesis · B.Sc. Biology · Systems Medicine of the Liver · Humboldt University of Berlin · 2025

Development of a whole-body PBPK model of glimepiride based on curated clinical data, investigating pharmacokinetic variability due to renal and hepatic impairment, bodyweight and CYP2C9 genetic variants.

Bachelor’s Thesis PDF